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4 - Long-term potentiation and long-term depression
- from Section A1 - Cellular and molecular mechanisms of neural plasticity
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- By Zafir I. Bashir, Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK, Peter V. Massey, Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK
- Edited by Michael Selzer, University of Pennsylvania, Stephanie Clarke, Université de Lausanne, Switzerland, Leonardo Cohen, National Institute of Mental Health, Bethesda, Maryland, Pamela Duncan, University of Florida, Fred Gage, Salk Institute for Biological Studies, San Diego
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- Book:
- Textbook of Neural Repair and Rehabilitation
- Published online:
- 05 March 2012
- Print publication:
- 16 February 2006, pp 60-78
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Summary
This chapter concentrates on the basic mechanisms that are thought to underlie induction and expression of long-term plasticity (LTP). LTP has been demonstrated at all of the major synapses in the hippocampus. Activity-dependent LTP is a commonly observed feature of the neocortex and does not differ from the hippocampus in its induction or expression mechanisms. The induction and/or the magnitude of LTP and long-term depression (LTD) can be affected by prior activity that in itself does not produce observable changes in synaptic efficacy. Thus there is some plastic change of a different, or meta, form that influences traditional synaptic plasticity. N-methyl-D-aspartate receptors (NMDAR)-mediated synaptic transmission can undergo potentiation and depression, and given the critical role for NMDARs in LTP and LTD induction it is apparent that any change in NMDAR synaptic transmission brought about by a priming stimulus could have dramatic consequences for induction of LTP and LTD.
Looking Backward, Looking Forward: MLA Members Speak
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- Journal:
- PMLA / Publications of the Modern Language Association of America / Volume 115 / Issue 7 / December 2000
- Published online by Cambridge University Press:
- 23 October 2020, pp. 1986-2078
- Print publication:
- December 2000
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